Peritoneal clearance and transport of methylglyoxal.

risk, including losartan, diuretics, fibrates and nonsteroidal anti-inflammatory drugs, and the presence of metabolic syndrome as defined by ATP III criteria. We found the odds ratios to be attenuated suggesting the presence of some confounding by these factors. However, the original finding in our paper [1] of a positive association between serum uric acid and CKD remained the same. Second, Dr Solak mentions that the observed association between serum uric acid and CKD in our paper may be due to the metabolic syndrome. To examine this hypothesis, we additionally adjusted for metabolic syndrome as a covariate in the multivariable model (see the multivariable model 2 in Table 1). We found the odds ratios to be slightly attenuated suggesting the presence of some confounding by metabolic syndrome. However, the original finding in our paper [1] of a positive association between serum uric acid and CKD remained the same. Third, Dr Solak mentions that the observed association between serum uric acid and CKD in our paper may be due to different patterns of drug use or dietary patterns, including fructose intake. To examine the role of different patterns of drug use, we additionally adjusted for the use of losartan, diuretics, fibrates and nonsteroidal antiinflammatory drugs as a covariate in the multivariable model (see the multivariable model 2 in Table 1). We found the odds ratios to be slightly attenuated, but the original conclusion from our study [1] of a positive association between serum uric acid and CKD remained robust. Unfortunately, we did not have data on dietary factors to examine the role of fructose intake as a confounder. Fourth, Dr Solak suggests the use of an estimated glomerular filtration rate (eGFR) cutoff instead of a serum creatinine cutoff to perform the sensitivity analysis. To address this point, we have now performed a new sensitivity analysis excluding subjects with eGFR values <30 mL/ min/1.72 m. Here we found the odds ratios to be slightly accentuated, and the original conclusion from our study [1] of a positive association between serum uric acid and CKD remained robust. In conclusion, within reasonable limits, we have shown that our findings [1] of a positive association between serum uric acid and CKD remained robust even after multiple sensitivity analyses. We agree with Dr Solak that data from longitudinal studies are needed to confirm this association. Conflict of interest statement. None declared.